I-API Donepezil HCl CAS 120011-70-3 ye-Alzheimer's Disease

Inkcazelo emfutshane:

I-Donepezil Hydrochloride yityuwa ye-hydrochloride ye-piperidine derivative kunye nomsebenzi we-neurocognitive-enhancing.I-Donepezil ibuyisela umva i-acetylcholinesterase, ngaloo ndlela ivala i-hydrolysis ye-neurotransmitter acetylcholine kwaye, ngenxa yoko, yandisa umsebenzi wayo.

Qhagamshelana: Erica Zheng

Email: erica@zhuoerchem.com

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Iithegi zeMveliso

Inkcazo

I-Donepezil isetyenziselwa ukuphatha ukudideka okunxulumene nesifo se-Alzheimer.

Inkcazo:

Igama lemveliso	I-Donepezil Hydrochloride
Igama leMchiza	1h-inden-1-enye,2,3-dihydro-5,6-dimethoxy-2-((1-(phenylmethyl)-4-piperidinyl)me
Elinye Igama	Donepezil hcl;Donezepilhydrochloride;DonepezilHydrochloride(200mg);2-((1-Benzylpiperidin-4-yl)Methyl)-5,6-diMethoxy-2,3-dihydro-1H-inden-1-onehydrochloride;2,3-Dihydrochloride;2,3-Dihydrochloride; -5,6-diMetChemicalbookhoxy-2-[[1-(phenylMethyl)-4-piperidinyl]Methyl]-;2-(1-Benzyl-4-piperidylmethyl)-5,6-dimethoxy-1-indanoneHydrochloride;Donepezil(Aricept );DonepezilHydrochlorideForMⅠ
Inombolo yeCAS	120011-70-3
Ifomula yeemolekyuli	I-C24H30ClNO3
Ubunzima beFormula	415.95
Imbonakalo	Emhlophe ukuya kumhlophe kwikristale eqinileyo
Isivavanyi	98.0% min
Indawo yokunyibilika	220-222 °C
Indawo yokubilisa	527.9 C Kwi-760 MmHg
Iphakheji	20kg/bag/drum, 25kg/bag/drum, okanye njengoko ubufuna
Ugcino	Gcina isikhongozeli sivalwe ngokuqinileyo kwindawo eyomileyo nepholileyo.Musa ukuveza ukukhanya kwelanga.
I-COA kunye ne-MSDS	Iyafumaneka
Isicelo	Ngenjongo yophando

Isatifikethi soHlahlelo/COA:

INTO YOVAVANYO	INGCACISO	IZIPHUMO
Imbonakalo	Kumhlophe ukuya kumgubo omhlophe wekristale	Iyahambelana
Ukunyibilika	I-soluble ngokukhululekileyo kwi-chloroform, i-soluble emanzini kunye ne-Acetic acid, i-soluble kancinane kwi-Acetonitrile kunye ne-ethanol, i-insoluble kwi-Ethylacetoacetate kunye ne-n-hexane.	Iyahambelana
Ukuchongwa	(1)Ngokufunxwa kwe-IR,Ukuhambelana nomgangatho wokusebenza.	Iyahambelana
	(2) Ixesha lokugcinwa kwencopho enkulu yesampulu kufuneka ihambelane naleyo yomgangatho wokusebenza.	Iyahambelana
	(3) Uvavanyo lwekloridi.Uphendula kuvavanyo lweChlorides.	Iyahambelana
Amanzi	≤0.4%	0.31%
Intsalela ekutshisweni	≤0.1%	0.02%
Into enxulumeneyo	Desbenzyl donepezl^a≤0.15% I-analog ye-Donepezil pyridine^b≤0.15% I-Donepezilzilbenzyl bromide^c≤0.15% Dehydrodeoxy donepezil^d≤0.15% Deoxy donepezil^e≤0.15% Nakuphi na ukungahlambuluki okukodwa okungaziwayo≤0.10% Iyonke ≤0.5%	Ayifunyaniswanga Ayifunyaniswanga 0.02% Ayifunyaniswanga Ayifunyaniswanga 0.05% 0.18%
Intsimbi enzima	≤20ppm	≤20ppm
Izinyibilikisi ezishiyekileyo	I-Methanol≤0.3%I-Ethanol≤0.5%I-Ethyl acetate≤0.5% iToluene≤0.089% Iacetic acid≤0.5%	Ayifunyaniswanga Ayifunyaniswanga Ayifunyaniswanga Ayifunyaniswanga Ayifunyaniswanga
Isivavanyi	Kwisiseko esomileyo, uC₂₄H₂₉NO₃·I-HCl kufuneka ibe yi-98.0% ukuya kwi-102.0%.	99.52%