Olivetol, ekwaziwa ngokuba yi-5-pentylresorcinol, yikhompawundi eyenzeka ngokwemvelo efumene ingqwalasela emandla kwiminyaka yakutshanje ngokusetyenziswa kwayo kwezamayeza kunye neshishini.Yimolekyuli eyandulela i-biosynthesis yeekhompawundi ezahlukeneyo, kubandakanya i-cannabinoids efunyenwe ngokuyintloko kwisityalo se-cannabis.Ukuqonda i-biosynthesis yeolivetolKubalulekile ukuqonda amandla ayo kwaye uphonononge iindlela ezahlukeneyo zokusebenza.
I-biosynthesis yeOlivetoliqala nge-condensation yeemolekyuli ezimbini ze-malonyl-CoA, ezivela kwi-acetyl-CoA, ngokusebenzisa isenzo se-enzyme ebizwa ngokuba yi-polyketide synthase.Oku kusabela koxinzelelo kukhokelela ekwenziweni kwekhompawundi ephakathi ebizwa ngokuba yi geranyl pyrophosphate, isandulela esiqhelekileyo kwi-biosynthesis yeemveliso ezahlukeneyo zendalo, kubandakanya i-terpenes.
I-Geranyl pyrophosphate iye ke iguqulelwe kwi-asidi yomnquma ngothotho lweentshukumo ze-enzymatic.Inyathelo lokuqala libandakanya ukudlulisa iqela le-isoprenyl ukusuka kwi-geranyl pyrophosphate ukuya kwi-molecule ye-hexanoyl-CoA, ukwenza i-compound ebizwa ngokuba yi-hexanoyl-CoA olive acid cyclase.Le ndlela yokwenza ibhayisekile yenziwa yi-enzyme ebizwa ngokuba yi-hexanoyl-CoA:olivelate cyclase.
Inyathelo elilandelayo ukungenaolivetolI-biosynthesis ibandakanya ukuguqulwa kwe-hexanoyl-CoA olivetate cyclase ibe yifom esebenzayo ebizwa ngokuba yi-tetraketide ephakathi.Oku kuphunyezwa ngoluhlu lwee-enzymatic reactions ezibangelwa yi-enzymes ezifana ne-chalcone synthase, i-stilbene synthase, kunye ne-resveratrol synthase.Ezi mpendulo zikhokelela ekwakhiweni kwe-tetraketide intermediates, ezithi ke ziguqulelwe kwi-olivetol ngesenzo se-polyketide reductase.
KanyeolivetolI-synthesized, inokuguqulwa ngakumbi kwiintlobo ezahlukeneyo, kubandakanywa i-cannabinoids, ngokusebenzisa isenzo se-enzymes ezifana ne-cannabidiolic acid synthase kunye ne-delta-9-tetrahydrocannabinolic acid synthase.Ezi enzymes zibangela ukuxinana kweolivetolkunye ne-geranyl pyrophosphate okanye ezinye iimolekyuli zangaphambili ukwenza ii-cannabinoids ezahlukeneyo.
Ukongeza kwindima yayo kwi-cannabinoid biosynthesis,olivetolIfunyenwe ukuba inezinto ezinokuthi zibe ne-antifungal kunye ne-antioxidant.Uphando luye lwabonisa ukubaolivetolinokuthintela ukukhula kweentlobo ngeentlobo zeentsholongwane zokungunda, okwenza kube ngumgqatswa othembisayo wokuphuhliswa kwamachiza e-antifungal.Ukongeza,olivetolibonakaliswe ukuba inomsebenzi onamandla wokutshabalalisa i-radicals yamahhala, eyi-molecule esebenzayo kakhulu enokubangela umonakalo kwiiseli kunye nezicubu.Le propati antioxidant yeolivetolicebisa ukusetyenziswa kwayo ekuphuhliseni ii-agent zonyango kunyango lwezifo ezinxulumene noxinzelelo lwe-oxidative.
Isishwankathelo, i-biosynthesis yeolivetolibandakanya ukujiya kweemolekyuli ze-malonyl-CoA, ezilandelwa luthotho lweentshukumo ze-enzymatic, ezikhokelela ekwakhekeniolivetol.Le khompawundi isebenza njengemolekyuli yangaphambili kwi-biosynthesis ye-cannabinoids kunye nezinye iimveliso zendalo.Ukuqonda indlela ye-biosynthetic yeOlivetolibaluleke kakhulu ekuphuhliseni usetyenziso olunokubakho kwiinkalo zamachiza kunye nezoshishino.Uphando olongezelelweyo kwi-biosynthesis yeolivetolkunye nezinto eziphuma kuzo zingakhokelela ekufunyanweni kweekhompawundi ezintsha zonyango kunye noncedo ekuphuhliseni amachiza amatsha.
Ixesha lokuposa: Nov-13-2023