Uvavanyo lubonise ukuphindaphindeka okuphezulu kweentsholongwane ze-quaternary ammonium njengonyango lweentsholongwane ezininzi, kubandakanya ii-coronavirus: ezi zisebenza ngokuvala i-lipid ekhuselayo egquma iintsholongwane ezifana ne-SARS-CoV-2 exhomekeke kuyo.Iikhompawundi zeQuaternary ammonium ziyacetyiswa ngokubanzi ukuba zibulale iintsholongwane kwaye kukho ngaphezu kwe-350 yeemveliso kuLuhlu lwe-EPA N: Izibulali-ntsholongwane ezisetyenziswa ngokuchasene ne-SARS-CoV-2 (Izinto ezongezelelweyo. Ugxininiso lwesibulali-ntsholongwane kunye namaxesha oqhagamshelwano (ayanyaniswa neentsholongwane ezininzi) kuninzi lwezokubulala iintsholongwane. iikhemikhali ezikuluhlu lwe-EPA ziye zaxelwa kwaye> i-140 ingayicima intsholongwane kwimizuzu nje embalwa (18).
Olu lwazi lusikhokelele kukhangelo olukhulu lweekhompawundi ze-quaternary ammonium ezinomsebenzi ochasene ne-coronavirus kunye nokuchongwa kweekhemikhali esele zivavanyiwe ekliniki kwaye ezinokusetyenziswa njengonyango olunokubakho lwe-COVID-19.Enye yee-disinfectants eziye zabonakala ziyonakalisa iintsholongwane (i-Supplementary Material) kwaye isetyenziswa ngokubanzi kwiimveliso zokhathalelo lomntu yi-cetylpyridinium chloride.Le khompawundi ifunyanwa ikakhulu kukuhlamba umlomo kwaye idweliswe yi-FDA njengeNgqwalaselwe Jikelele njengeKhuselekileyo (GRAS) kangangokuba ikwasetyenziswa njenge-antimicrobial agent kwimveliso yenyama kunye neenkukhu (ukuya kuthi ga kwi-1%).I-Cetylpyridinium chloride isetyenziswe kwizilingo ezininzi zekliniki, kubandakanywa njengonyango oluchasene nosulelo lokuphefumla oluqinisekisa ukusetyenziswa kwayo njenge-antiviral.I-Cetylpyridinium ikhuthaza ukungasebenzi kwentsholongwane ngokutshabalalisa i-capsid kunye nesenzo sayo se-lysosomotropic, njengoko kuxoxwe ngasentla, eqhelekileyo kwiikhompawundi ze-quaternary ammonium.Oku kuphakamisa umbuzo wokuba ingaba amanye amayeza achongiweyo ane-antiviral action ngokuchasene ne-SARS-CoV-2 in vitro aziphatha ngendlela efanayo na, oko kukuthi, anokuyitshabalalisa i-capsid yentsholongwane kunye nokuqokelela kwi-lysosome okanye i-endosomes kwaye ekugqibeleni athintele ukungena kwentsholongwane.Uphononongo olongezelelweyo olupapashiweyo lucebise ukuba esi siphumo sinokuncitshiswa ngokusetyenziswa kweCathepsin-L inhibitors.
I-Cetylpyridinium chloride(CPC)
Iikhompawundi ze-quaternary ammonium kunye nomsebenzi owaziwayo we-coronavirus
| Imolekyuli | Umsebenzi we-Antiviral | Inkqubo | I-FDA ivunyiwe | Usebenzisa |
| I-ammonium chloride | I-Murine coronavirus, i-hepatitis C, | I-Lysosomotropic | Ewe | Ukusetyenziswa okuhlukeneyo kubandakanya i-acidosis ye-metabolic. |
| Cetylpyridinium chloride | Umkhuhlane, ihepatitis B, intsholongwane yepoliyo 1 | Ujoliso lwe-capsid kwaye i-lysosomotropic | Ewe, i-GRAS | I-Antiseptic, i-mouthwash, iilozenge zokukhohlela, iimveliso zokhathalelo lomntu, iiarhente zokucoca njl. |
Ixesha lokuposa: Aug-03-2021